48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer's Disease

Running, not enrolling · Not applicable

Conditions studied: Early Onset Alzheimer Disease

In brief

Researchers are trying to determine the frequency of seizures and epilepsy in patients with Early-onset Alzheimer's disease (EOAD) using a 48-hour computer assisted ambulatory electroencephalogram.

Key facts

Study ID

NCT04002583

Run by

Mayo Clinic

People needed

20

Starts

2020-02-19

Expected to finish

2026-12-01

Last updated by the study team

2026-03-05

Who can join

Age: 40 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Meets core clinical criteria for non-AD dementia.
• Two or more first degree relatives with a history of EOAD suggestive of autosomal dominant transmission, unless known pathogenic mutations in APP, PSEN1, PSEN2 have been excluded.
• Known mutation in an ADAD gene (APP, PSEN1, PSEN2) or other autosomal dominant genes associated with other neurodegenerative disorders.
• MRI scans with evidence of infection or focal lesions, cortical strokes, multiple lacunes (single lacune is allowable unless it meets criteria for strategic lacune affecting cognition)
• Any significant systemic illness or unstable medical condition, which could lead to difficulty complying with the protocol (at the discretion of the Site PI)
• Medical history of a brain disorder other than the disorder causing dementia except for headache.
• Deemed ineligible by the Site PI for any other reason.

Where it is running

• Mayo Clinic in Florida — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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