A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
Running, not enrolling · Phase 3
Conditions studied: Mantle Cell Lymphoma; Non-Hodgkin Lymphoma
In brief
This is a randomized study to compare the efficacy and safety of zanubrutinib plus rituximab versus bendamustine plus rituximab in previously untreated participants with mantle cell lymphoma (MCL) who are not eligible for stem cell transplantation.
Key facts
- Study ID
- NCT04002297
- Run by
- BeOne Medicines
- People needed
- 510
- Starts
- 2019-08-20
- Expected to finish
- 2031-09-30
- Last updated by the study team
- 2026-05-18
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
- Beth Israel Deaconess Medical Center (Bidmc) — Boston, Massachusetts, United States
- University of Michigan Health System — Ann Arbor, Michigan, United States
- Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
- Icahn School of Medicine At Mount Sinai — New York, New York, United States
- Clinical Research Alliance, Inc — Westbury, New York, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- West Penn Hospital — Pittsburgh, Pennsylvania, United States
- The University of Texas Md Anderson Cancer Center — Houston, Texas, United States
- Joe Arrington Cancer Research and Treatment Center — Lubbock, Texas, United States
- Seattle Cancer Care Alliance — Seattle, Washington, United States
- Canberra Hospital — Garran, Australian Capital Territory, Australia
- Concord Repatriation General Hospital — Concord, New South Wales, Australia
- The Tweed Valley Hospital — Cudgen, New South Wales, Australia
- Saint Vincents Hospital Sydney — Darlinghurst, New South Wales, Australia
- Gosford Hospital — Gosford, New South Wales, Australia
- Calvary Mater Newcastle — Waratah, New South Wales, Australia
- Sunshine Coast Hospital and Health Service — Birtinya, Queensland, Australia
- Icon Cancer Foundation — South Brisbane, Queensland, Australia
- Flinders Medical Centre — Bedford PK, South Australia, Australia
- Royal Hobart Hospital — Hobart, Tasmania, Australia
- Monash Health — Clayton, Victoria, Australia
- St Vincents Hospital Melbourne — Fitzroy, Victoria, Australia
- Peninsula Private Hospital — Frankston, Victoria, Australia
- Chao Family Comprehensive Cancer Center — Orange, California, United States
Full record on ClinicalTrials.gov
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