Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis

Completed · Phase 2 · Has a placebo group

Conditions studied: Endometriosis, Ovarian Hyperstimulation

In brief

Randomized double blinded placebo-controlled trial to evaluate the impact of ovarian hyperstimulation on endometriosis-related symptoms and to evaluate the impact of letrozole use during ovarian hyperstimulation with respect to endometriosis-related symptoms, embryo/egg quality and quantity, and pregnancy rates.

Key facts

Study ID

NCT04002141

Run by

University of California, San Francisco

People needed

60

Starts

2019-09-17

Expected to finish

2025-01-01

Last updated by the study team

2026-01-28

Who can join

Age: 18 and older, up to 42. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 18-42 years
• Planning to undergo controlled ovarian hyperstimulation
• Prior diagnosis of endometriosis by one of the following: (1) surgical diagnosis (2) endometrioma on pelvic ultrasound
• Planning to freeze all retrieved oocytes/embryos prior to transfer

You may not qualify if…

• Hypersensitivity to letrozole
• Any significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow-up, or interpretation of study results

Where it is running

• UCSF Center for Reproductive Health — San Francisco, California, United States

Full record on ClinicalTrials.gov

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