A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumors
Completed · Phase 1/Phase 2
Conditions studied: Malignancy, Non-hodgkin Lymphoma, Multiple Myeloma, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, Head and Neck Cancer, DLBCL, Mantle Cell Lymphoma, Follicular Lymphoma, Pancreatic Cancer, CLL, Small Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Triple Negative Breast Cancer
In brief
This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1/2 study. The study objectives are to assess the safety, tolerability and pharmacokinetics (PK) of CYT-0851 in patients with relapsed/refractory B-cell malignancies and advanced solid tumors and to identify a recommended Phase 2 dose as a monotherapy and in combination with chemotherapy for evaluation in these patients.
Key facts
- Study ID
- NCT03997968
- Run by
- Cyteir Therapeutics, Inc.
- People needed
- 169
- Starts
- 2019-10-09
- Expected to finish
- 2024-12-20
- Last updated by the study team
- 2024-12-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Francisco — San Francisco, California, United States
- Stanford Comprehensive Cancer Center — Stanford, California, United States
- Sarah Cannon Research Institute at HealthONE — Denver, Colorado, United States
- Florida Cancer Specialists and Research Institute — Sarasota, Florida, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Mayo Clinic — Rochester, Minnesota, United States
- John Theurer Cancer Center at HUMC — Hackensack, New Jersey, United States
- NYU Langone Health — New York, New York, United States
- Oklahoma University-Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Thomas Jefferson University, Sidney Kimmel Cancer Center — Philadelphia, Pennsylvania, United States
- Sarah Cannon Research Institute at Tennessee Oncology — Nashville, Tennessee, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- University of Washington Seattle Cancer Center — Seattle, Washington, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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