Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

Recruiting now

Conditions studied: Hearing Loss, Sensorineural

In brief

Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

Key facts

Study ID

NCT03996824

Run by

Institut Pasteur

People needed

100

Starts

2019-02-19

Expected to finish

2027-02-18

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient ≥ 18 years old
• Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
• Informed consent obtained
• Patients with a french social protection (AME excluded)

You may not qualify if…

• Intravestibular or intra-cochlear extension of the tumor
• Pregnant woman
• Patient with administrative control
• Medical contra-indication

Where it is running

• Hôpital de Bicêtre — Le Kremlin-Bicêtre, Île-de-France Region, France (enrolling)
• Hôpital Pitié-Salpétrière — Paris, Île-de-France Region, France (enrolling)

Full record on ClinicalTrials.gov

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