A Clinical Trial for Self-Injurious Behavior

Running, not enrolling · Not applicable

Conditions studied: Self-Injurious Behavior

In brief

At least one quarter of the 18 million persons in the US with intellectual and developmental disabilities engage in self-injurious behavior (SIB), which can result in injuries, disfigurement, and loss of function (e.g., blindness). SIB that persists in the absence of social reinforcement has been referred to as automatically maintained SIB (ASIB). Research has shown that the sensitivity of ASIB to disruption by alternative reinforcement is identifiable in a standardized assessment, predicts response to treatment, and provides a quantifiable basis for subtyping ASIB. This research has also identified two subtypes that are highly resistant to behavioral treatment using reinforcement alone, necessitating the use of protective equipment and other procedures to minimize injury. The proposed study is a clinical trial that will allow systematic comparison of the effectiveness of two behavioral treatments targeting treatment-resistant subtypes of ASIB.

Key facts

Study ID

NCT03995966

Run by

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

People needed

16

Starts

2019-06-04

Expected to finish

2026-08-31

Last updated by the study team

2026-02-18

Who can join

Age: 4 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals with intellectual disabilities
• Admitted to the Neurobehavioral Unit Inpatient program at the Kennedy Krieger Institute
• Between the ages of 4 to 25 years
• Exhibits either Subtype 2 or 3 automatically maintained self-injurious behavior

You may not qualify if…

• Children in foster care
• Non-English speakers
• Individuals with a medical condition that could interfere with participation, or place an individual at increased risk

Where it is running

• Kennedy Krieger Institute — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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