Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704)

Completed

Conditions studied: Hematologic Malignancy

In brief

Prospective observational multicenter study of allogeneic Hematopoietic Stem Cell Transplantation (HCT) in recipients 60 years and older to assess important determinants of health status to be combined into a composite health risk model to improve risk assessment of non-relapse mortality (NRM).

Key facts

Study ID

NCT03992352

Run by

Center for International Blood and Marrow Transplant Research

People needed

1229

Starts

2019-07-19

Expected to finish

2023-05-30

Last updated by the study team

2024-02-06

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is > 60.0 years old at time of enrollment.
• Hematological malignancy as an indication for allogeneic transplantation.
• Eligible for allogeneic transplantation based on institutional standards
• First allogeneic transplant planned. Any conditioning regimen and allogeneic donor is acceptable.
• Able to speak and read English. Spanish, and Mandarin will be acceptable when sites have ability to perform healthcare provider tests in those languages.
• Written informed consent

You may not qualify if…

• Prior allogeneic HCT

Where it is running

• Mayo Clinic Arizona and Phoenix Children's Hospital — Phoenix, Arizona, United States
• City of Hope National Medical Center — Duarte, California, United States
• University of California San Francisco — San Francisco, California, United States
• Stanford University — Stanford, California, United States
• University of Florida — Gainesville, Florida, United States
• AdventHealth Orlando — Orlando, Florida, United States
• Memorial Cancer Institute — Pembroke Pines, Florida, United States
• H. Lee Moffitt Cancer Center — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northside Hospital — Atlanta, Georgia, United States
• University of Chicago Medicine — Chicago, Illinois, United States
• Loyola University Medical Center — Maywood, Illinois, United States
• Indiana Blood and Marrow Transplantation — Beech Grove, Indiana, United States
• Indiana University — Indianapolis, Indiana, United States
• University of Kansas, Blood and Marrow Transplant Program — Kansas City, Kansas, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• UMass Memorial Medical Center — Worcester, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Karmanos Cancer Center — Detroit, Michigan, United States
• Henry Ford Hospital Bone Marrow Transplant Program — Detroit, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mayo Clinic Rochester — Rochester, Minnesota, United States
• Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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