Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

Running, not enrolling · Phase 1

Conditions studied: Hormone Receptor Positive Metastatic Breast Cancer

In brief

This study will test any good and bad effects of aerobic exercise performed while you are receiving the usual first-line treatment for metastatic breast cancer. The researchers think that exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.

Key facts

Study ID

NCT03988595

Run by

Memorial Sloan Kettering Cancer Center

People needed

54

Starts

2019-06-12

Expected to finish

2026-08-01

Last updated by the study team

2025-08-27

Who can join

Age: 19 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically-confirmed, HR-positive (ER and/or PR), HER2-negative metastatic breast cancer (MBC)
• Postmenopausal status defined by lack of menses for 2 years, oophorectomy, or medical ovarian suppression
• Receiving first line endocrine-based therapy (tamoxifen, aromatase inhibitor, or fulvestrant; concurrent molecular therapy also allowed)
• Sedentary (i.e., <60 minutes / week of exercise)
• Age >18 years
• BMI ≥ 18.5
• Cleared for exercise participation as per screening clearance via PAR-Q+
• Cleared for study participation as per screening consultation with an MSK Exercise Physiologist
• Willingness to comply with all study-related procedures
• Patients with "treated and stable" brain lesions of a duration of ≥ 2 months may be enrolled

You may not qualify if…

• Life expectancy <6 months
• Enrollment onto any other therapeutic investigational study
• Mental impairment leading to inability to cooperate
• Concurrent participation in weight loss or other exercise programs

Where it is running

• Indiana University (Data Collection Only) — Indianapolis, Indiana, United States
• Johns Hopkins Hospital (Data Collection Only) — Baltimore, Maryland, United States
• Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Cancer Center @ Suffolk (Limited protocol activity) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Montefiore Health Systems (Montefiore Medical Center) (Data Collection Only) — The Bronx, New York, United States
• Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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