A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With Kidney Stones

Completed · Not applicable

Conditions studied: Kidney Calculi

In brief

Patients with nephrolithiasis and evidence of hypocitraturia or aciduria who would otherwise be started on potassium citrate, can achieve similar urine alkalization with 500-1000 mL of daily low calorie orange juice consumption.

Key facts

Study ID

NCT03984409

Run by

Indiana University

People needed

22

Starts

2019-06-01

Expected to finish

2020-11-01

Last updated by the study team

2020-11-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Between 18 and 75 year of age.
• History of kidney stone disease with available stone analysis
• Evidence of aciduria or hypocitraturia on 24 hour urinalysis (24 hr citrate male <450 mg/day female <550 mg/day) or aciduria (urine pH < 5.8)
• Ability to drink Kroger low calorie orange juice beverage
• If subject with history of diabetes mellitus, must have HgA1c < 7.5 and willing to check daily blood sugars.

You may not qualify if…

• • Less than 18 or older than 75 years of age
• Allergies to low calorie orange juice, including intolerance because of side effects including (but not limited to): gastrointestinal symptoms, headaches, weight gain, unable to drink because of taste.
• Poorly controlled diabetic (HgA1c >7.5)
• No evidence of hypocitraturia or aciduria on 24 hour urinalysis
• Unable to afford potassium citrate therapy or tolerate medication because of side effects.
• Unwilling to perform 3 24-hour urine collections

Where it is running

• Indiana University Health Methodist Hospital — Indianapolis, Indiana, United States
• Indiana University Health Physicians Urology — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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