L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients

Running, not enrolling · Phase 4 · Has a placebo group

Conditions studied: Chronic Kidney Disease

In brief

Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. A potential signal driving sympathetic nerve activity (SNA) involves accumulation of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). ADMA is elevated in CKD and is a strong, independent predictor of future cardiovascular events in these patients. . The goal of this study is to determine whether overcoming the accumulation of endogenous ADMA with acute L-arginine infusion reduces SNA in CKD patients.

Key facts

Study ID

NCT03982160

Run by

The University of Texas at Arlington

People needed

15

Starts

2018-02-01

Expected to finish

2026-12-31

Last updated by the study team

2026-06-18

Who can join

Age: 35 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• CKD patients classified as Stage 3 and 4 of National Kidney Foundation Classification with estimated glomerular filtration rate (GFR) between 15 and 59 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula based on serum creatinine, age, gender, and race.
• Men and women 35 to 75 years of age

You may not qualify if…

• myocardial infarction
• heart failure
• anemia (hemoglobin <8 g/dl)
• cancer with current treatment
• previous organ transplantation
• immunosuppressant therapy
• human immunodeficiency virus infection
• pregnancy and/or lactating
• current tobacco use
• taking menopausal drugs (estradiol)
• treatment for diabetic neuropathy
• resting heart rate ≥ 100 bpm and
• systolic blood pressure ≤ 90 mmHg

Where it is running

• University of Delaware — Newark, Delaware, United States
• UT Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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