Anti-Cancer Effects of Carvedilol With Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells
Withdrawn before enrolling · Early Phase 1
Conditions studied: Glioblastoma, Glioblastoma Multiforme
In brief
The purpose of this pilot study is to evaluate the addition of carvedilol with standard of care treatment to determine if it will improve progression-free survival in the front line setting in patients with glioblastoma multiforme (GBM). In addition, monitoring of circulating tumor cells (CTCs) by a real-time reverse transcriptase polymerase chain reaction (qRT-PCR) assay to correlate with the clinical findings.
Key facts
- Study ID
- NCT03980249
- Run by
- West Virginia University
- People needed
- 0
- Starts
- 2020-09-01
- Expected to finish
- 2022-06-01
- Last updated by the study team
- 2021-04-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must have histologically or cytologically confirmed WHO Grade IV Glioblastoma
- Subjects must have not received previous chemotherapy or radiation therapy for GBM
- Subjects must have systolic blood pressure greater than or equal to 90 and heart rate >59
- Subjects who are on beta-blockers for other etiologies may enroll on study and switch therapy to carvedilol if deemed medical appropriate per treating physician
You may not qualify if…
- Subjects receiving any other investigational agents
- Subjects who have severe and uncontrolled asthma, COPD
- Systolic blood pressure <90 mmHg or HR <60 bpm without antihypertensive medications at baseline
- Subjects with uncontrolled illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Allergy to beta blockers
Where it is running
- WVU Cancer Institute - Mary Babb Randolph Cancer Center — Morgantown, West Virginia, United States
Full record on ClinicalTrials.gov
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