Medication Adherence With Telehealthcare Medication Therapy Management

Completed · Not applicable

Conditions studied: Uncontrolled Asthma, Young Adults

In brief

Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of Adolescents and Young Adults (AYA) with uncontrolled asthma who have poor adherence with prescribed Inhaled corticosteroid (ICS) therapy.

Key facts

Study ID

NCT03978936

Run by

Johns Hopkins University

People needed

375

Starts

2019-11-18

Expected to finish

2025-06-30

Last updated by the study team

2026-06-26

Who can join

Age: 12 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 12 through 35 years
• Speaks English or Spanish
• Physician diagnosed asthma (without any other co-morbid pulmonary disease)
• Prescribed ICS treatment for at least 3 months prior to screening
• Adherence to Refills and Medication Scale (ARMS) 7-item questionnaire score of >8 (low or moderate adherence)
• Current use of albuterol metered dose inhaler (MDI) for rescue: ProAir, Ventolin, albuterol sulfate (from Prasco or Teva)
• Uncontrolled asthma:
• Symptomatic asthma defined as 3 of the following in the past 4 weeks:
• Daytime symptoms of asthma more than twice per week
• Any night awakening due to asthma
• Rescue inhaler use for symptoms more than twice per week
• Any activity limitation due to asthma; OR
• Asthma Control Test score ≤19
• Has iPhone or Android smart phone with Short Message Service (SMS)
• Has access to reliable WiFi service and a device with capability for telemedicine study visits
• Ability to understand and willingness to sign consent documents
• Evidence of Propeller sensor connection in the 4-week run-in period

You may not qualify if…

• Use of an investigational treatment in the previous 30 days.
• Previous enrollment in MATCH Structured Interviews ( Aim 1)
• Currently enrolled in an intervention trial
• Currently uses an ICS not compatible with the Propeller sensor
• Inability to comply with study procedures, including:
• Inability or unwillingness to provide informed consent (or assent in the case of a minor).
• Inability to perform study measurements.
• inability to be contacted by phone via calls and /or text messaging
• Not willing to have video chat
• Any condition(s) in the opinion of the physician that puts the participant at risk from participating in the study

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of Arizona — Tucson, Arizona, United States
• University of California at San Francisco — San Francisco, California, United States
• National Jewish Medical and Research Center — Denver, Colorado, United States
• Nemours Children's Specialty Care — Jacksonville, Florida, United States
• University of Florida College of Medicine — Jacksonville, Florida, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Northwestern University — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Chicago Hospitals — Chicago, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• New York University School of Medicine — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Mount Sinai National Jewish Health Respiratory Institute; Icahn School of Medicine — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Temple University — Philadelphia, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States
• Vermont Lung Center at The University of Vermont — Colchester, Vermont, United States
• Pacific Northwest Airways - VA Puget Sound Healthcare System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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