Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Completed · Phase 2

Conditions studied: Preeclampsia Severe, Preeclampsia Postpartum

In brief

A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on postpartum hypertension.

Key facts

Study ID

NCT03978767

Run by

Washington University School of Medicine

People needed

287

Starts

2019-06-10

Expected to finish

2026-06-15

Last updated by the study team

2026-06-22

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women at > 23 weeks gestational age undergoing vaginal or cesarean delivery at Barnes-Jewish Hospital with:
• An antepartum diagnosis of preeclampsia with severe features
• Pre-eclampsia with severe features will be defined as:
• Elevated blood pressure ≥ 160/110, or
• Pre-eclampsia in the setting of thrombocytopenia (platelet count < 100,000), or
• Impaired liver function (AST elevated to twice upper limit of normal), or
• Persistent epigastric pain, or
• Renal insufficiency (serum creatinine of 1.1 mg/dl or doubling of prior value), or
• Pulmonary edema, or
• New onset visual disturbance or headache unresponsive to therapy.

You may not qualify if…

• NSAID allergy
• Allergy to acetaminophen
• Antihypertensive use in this pregnancy prior to 20 weeks gestation
• Chronic kidney disease or Acute kidney injury with Creatine clearance less than 60 mL/min
• Inability to obtain consent
• Opioid abuse disorder
• Peptic ulcer disease.

Where it is running

• Barnes Jewish Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.