Dual-benefits of Aerobic and Resistance Training

Paused · Not applicable

Conditions studied: Sarcopenia, Aging, Disability Physical

In brief

This study evaluates the effect of three different exercise strategies on physical function in older adults. Participants will be randomly assigned to one of three exercise groups: resistance training, moderate-intensity continuous cycling on a stationary bicycle, and high-intensity interval training on a stationary bicycle.

Key facts

Study ID

NCT03978572

Run by

Ohio University

People needed

30

Starts

2019-02-01

Expected to finish

2021-09-30

Last updated by the study team

2020-09-16

Who can join

Age: 60 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 60-75 years with no significant health issues or conditions that, in the investigator's opinion, would limit the subject's ability to complete the study per protocol or that would impact the capability to get an accurate measurement of study endpoints.
• Body mass index between 18.0 and 35 kg/m2.
• Willingness to maintain current diet and adhere to the intervention programs described for the study and willing to undergo all testing procedures.
• Able to read, understand, and complete study-related questionnaires
• Able to read and understand, and willing to sign the informed consent form (ICF).
• 6-minute walk distance of 450-725 meters for men and 400-675 meters for women.

You may not qualify if…

• Failure to provide informed consent.
• 6-minute walk distance below 450 meters or above 725 meters for men, below 400 meters or above 675 meters for women
• Any activities of daily living (ADL) disability (difficulty feeding, dressing, continence, bathing, toileting, and transferring).
• Lives in a nursing home or assisted living facility
• Known neuromuscular or neurological conditions affecting somatosensory or motor function or control (e.g., hemiplegia, multiple sclerosis, peripheral neuropathy, Parkinsons disease, Myasthenia Gravis, Ataxia, Apraxia, post-polio syndrome, mitochondrial myopathy, etc.).
• Unable to communicate because of severe hearing loss or speech disorder.
• Severe visual impairment, which would preclude completion of the assessments.
• Cancer requiring treatment currently or in the past 2 years (except primary non-melanoma skin cancer or in situ cervical cancer)
• Hospitalization (medical confinement for 24 hours), or immobilization, or major surgical procedure requiring general anesthesia within 12 weeks prior to screening, or any planned surgical procedures during the study period.
• Chronic or relapsing/remitting gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome.
• Known history of human immunodeficiency virus (HIV) antibody at screening.
• Use of systemic glucocorticoids.
• Any history of angina pectoris
• Any history of heart failure
• Any history of myocardial infarction
• Any coronary artery bypass graft or percutaneous coronary intervention
• Heart disease that limits exercise (valvular, congenital, ischaemic and hypertrophic cardiomyopathy)
• Complex ventricular arrhythmias or heart block
• Chronic obstructive pulmonary disease, cerebrovascular disease, or peripheral vascular disease
• Diabetes mellitus
• Severe neuropathy
• Mini-mental state exam score (MMSE) below 19
• Psychiatric conditions that warrant acute or chronic therapeutic intervention (e.g., major depressive disorder, bipolar disorder, panic disorder, schizophrenia) that in the investigators opinion may interfere with the conduct of study procedures
• Unable to undergo magnetic resonance imaging (MRI) (e. g. body containing any metallic medical devices or equipment, including heart pacemakers, metal prostheses, implants or surgical clips, any prior injury from shrapnel or grinding metal, exposure to metallic dusts, metallic shavings or having tattoos containing metallic dyes).
• Unable to reliably undergo exercise or strength tests described for this study.

Where it is running

• Ohio University — Athens, Ohio, United States

Full record on ClinicalTrials.gov

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