Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans

Running, not enrolling · Not applicable

Conditions studied: Traumatic Brain Injury

In brief

The primary purpose of this project is to determine the effect of morning bright light therapy (MBLT) on sleep in Veterans with traumatic brain injury (TBI). Secondarily, the project aims to identify blood-based brain biomarkers (BBBM) associated with sleep in Veterans. Specific Aim 1. Determine the effect of MBLT on sleep quality in Veterans (primary outcome). Specific Aim 2. Determine the effect of MBLT on downstream effectors of improved sleep, including cognition, mood, and quality of life measures in Veterans (exploratory outcomes). Specific Aim 3. Determine the effect of MBLT on levels of specific BBBM related to sleep, and whether changes in specific BBBM predict response to MBLT (secondary outcome). This study can now be completed 100% remotely.

Key facts

Study ID

NCT03968874

Run by

Portland VA Medical Center

People needed

300

Starts

2019-08-01

Expected to finish

2025-12-01

Last updated by the study team

2025-11-14

Who can join

Age: 18 and older, up to 88. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veteran
• English-speaking
• Accessible by phone

You may not qualify if…

• Decisional impairment
• Macular degeneration
• Bipolar disorder
• Shift work
• Currently using lightbox or negative ion generator

Where it is running

• Portland VA Medical Center — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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