Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline

Status unconfirmed · Phase 2

Conditions studied: Hives

In brief

Investigators will study the effects of topical doxycycline on cutaneous allergic early and late phase responses by determining allergen skin responses in each subject after a single application to allergen induced allergic swelling of 2% doxycycline in emollient.

Key facts

Study ID

NCT03968562

Run by

State University of New York - Downstate Medical Center

People needed

25

Starts

2019-05-15

Expected to finish

2022-05-14

Last updated by the study team

2021-10-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult (ages 18-75) outpatients with diagnosis of allergic rhino-conjunctivitis and/or asthma who have previously undergone epicutaneous skin prick testing with detection of at least one allergen positive, and who may or may not have had a serum IgE level done as part of their routine evaluation.

You may not qualify if…

• Subjects unable/unwilling to undergo cessation of oral antihistamines for five days prior to testing.
• Current use of oral steroids or other systemic immunosuppressants, including omalizumab (anti-IgE therapy) and anti-IL-5 therapy.
• Allergic asthmatics with current uncontrolled asthma.
• Pregnant women

Where it is running

• SUNY Downstate Medical Center — Brooklyn, New York, United States

Full record on ClinicalTrials.gov

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