Defocus Induced Changes on Choroidal Thickness

Completed · Not applicable

Conditions studied: Induced Defocus to the Retina

In brief

The goals of this study are to assess the short-term (10-60 minutes) effects of different magnitudes of myopic and hyperopic optical defocus on the transient thickness of the choroid in children and adults, as well as to assess the recovery period. Choroidal thickness will be measured non-invasively following 10-60 minutes of monocular exposure to -5 diopters to +5 diopters of optical defocus induced by spectacle lenses. The hypothesis is that choroidal thickness will increase with increasing myopic defocus and decrease with increasing hyperopic defocus. The relationship between the magnitude of defocus and the magnitude and direction of choroidal thickness change will be assessed.

Key facts

Study ID

NCT03954886

Run by

University of Houston

People needed

48

Starts

2018-05-15

Expected to finish

2021-12-31

Last updated by the study team

2022-03-17

Who can join

Age: 6 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 6 to 45 years of age (preliminary studies indicate that children under 6 cannot sit for imaging, and subjects over 45 do not respond to the optical defocus with expected choroidal thickness changes)
• Best corrected visual acuity of 20/25 or better in better-seeing eye

You may not qualify if…

• Age younger than 6 years or older than 45
• Best corrected visual acuity worse than 20/25 in better-seeing eye
• Ocular pathology or prior ocular injury
• Heavily-pigmented choroid that precludes accurate measurement of choroidal thickness

Where it is running

• University of Houston College of Optometry — Houston, Texas, United States

Full record on ClinicalTrials.gov

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