Pulmonary Hemodynamics During Exercise - Research Network
Recruiting now
Conditions studied: Pulmonary Circulation Diseases
In brief
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Key facts
- Study ID
- NCT03954574
- Run by
- Medical University of Graz
- People needed
- 1500
- Starts
- 2018-12-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2025-04-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
- Written informed consent of participating subjects after being fully briefed (for prospective analysis)
You may not qualify if…
- Patients with incomplete hemodynamic data at rest or exercise
- Patients without sufficient follow-up data (information on survival / lung transplantation)
- advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
- advanced heart failure with pulmonary arterial wedge pressure (PAWP) > 18 mmHg at rest
- uncontrolled systemic arterial hypertension (RR values > 160/100 mmHg at rest)
- FEV1<50% predicted
- TLC<60% predicted
Where it is running
- University of Arizona, Banner University Medical Center — Phoenix, Arizona, United States (enrolling)
- University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine — Los Angeles, California, United States (enrolling)
- Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA — Baltimore, Maryland, United States (enrolling)
- Massachusetts General Hospital, Cardiology Division and Pulmonary Unit — Boston, Massachusetts, United States (enrolling)
- Harvard Medical School, Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
- University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA — Minneapolis, Minnesota, United States (enrolling)
- Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine — Rochester, Minnesota, United States (enrolling)
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
- Royal Prince Alfred Hospital, Respiratory Medicine — Camperdown, Australia (enrolling)
- Medical University of Graz — Graz, Austria (enrolling)
- Free University of Brussels, Faculty of Medicine, Physiology — Brussels, Belgium (enrolling)
- University of São Paulo Medical School — São Paulo, Brazil (enrolling)
- Department of Cardiology, Aarhus University Hospital, Denmark — Aarhus, Denmark (enrolling)
- Université de Lorraine — Nancy, France (enrolling)
- Centre Chirurgical Marie Lannelongue, Thoracic and Vascular Surgery — Paris, France (enrolling)
- Centre de Référence de l'Hypertension Pulmonaire, Université ParisSud - Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris — Paris, France (enrolling)
- Sorbonne Universités, Neurophysiologie respiratoire expérimentale et clinique — Paris, France (enrolling)
- University of Cologne, Klinik III fuer Innere Medizin — Cologne, Germany (enrolling)
- Justus-Liebig-University Giessen, Department of Internal Medicine — Giessen, Germany (enrolling)
- University of Greifswald — Greifswald, Germany (enrolling)
- Thorax Clinic Heidelberg, Centre for Pulmonary Hypertension — Heidelberg, Germany (enrolling)
- Academic Teaching Hospital of the Julius Maximilian University of Würzburg — Würzburg, Germany (enrolling)
- University of Bologna — Bologna, Italy (enrolling)
- University of Rome La Sapienza, Cardiovascular and Respiratory Sciences — Roma, Italy (enrolling)
- VU Medisch Centrum, Pulmonology — Amsterdam, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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