A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Brain Contusion
In brief
The primary objective is to determine if BIIB093 reduces brain contusion expansion by Hour 96 when compared to placebo. The secondary objectives are to evaluate the effects of BIIB093 on acute neurologic status, functional outcomes, and treatment requirements, to further differentiate the mechanism of action of BIIB093 on contusion expansion by examining differential effects on hematoma and edema expansion, and to determine if BIIB093 improves survival at Day 90 when compared to placebo.
Key facts
- Study ID
- NCT03954041
- Run by
- Remedy Pharmaceuticals, Inc.
- People needed
- 92
- Starts
- 2019-10-06
- Expected to finish
- 2023-06-27
- Last updated by the study team
- 2024-11-27
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Scottsdale Healthcare Hospitals d/b/a HonorHealth — Scottsdale, Arizona, United States
- University of Arizona Medical Center — Tucson, Arizona, United States
- Yale New Haven Hospital — New Haven, Connecticut, United States
- Grady Memorial Hospital — Atlanta, Georgia, United States
- WellStar Medical Group Neurosurgery — Marietta, Georgia, United States
- Goodman Campbell Brain and Spine — Carmel, Indiana, United States
- University Medical Center New Orleans — New Orleans, Louisiana, United States
- University of Maryland Medical Center — Baltimore, Maryland, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Northwell Health — Manhattan, New York, United States
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- Vidant Medical Center — Greenville, North Carolina, United States
- Wake Forest Baptist Health Sciences — Winston-Salem, North Carolina, United States
- University of Cincinnati College of Medicine — Cincinnati, Ohio, United States
- Miami Valley Hospital — Dayton, Ohio, United States
- ProMedica Toledo Hospital — Toledo, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
- Rhode Island Hospital — East Providence, Rhode Island, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
- The University of Texas Health Science Center at Houston — Houston, Texas, United States
- University of Utah Health — Salt Lake City, Utah, United States
- Virginia Commonwealth University Medical Center — Richmond, Virginia, United States
- Barrow Neurological Institute — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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