Study of BHV-3241 in Participants With Multiple System Atrophy

Completed · Phase 3 · Has a placebo group

Conditions studied: Multiple System Atrophy

In brief

The purpose of this study is to compare the efficacy of verdiperstat (BHV-3241) versus placebo in participants with Multiple System Atrophy

Key facts

Study ID

NCT03952806

Run by

Biohaven Pharmaceuticals, Inc.

People needed

421

Starts

2019-07-29

Expected to finish

2022-06-30

Last updated by the study team

2023-09-29

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable or possible MSA according to consensus clinical criteria (Gilman et al 2008), including participants with MSA of either subtype (MSA-P or MSA-C).
• Able to ambulate without the assistance of another person, defined as the ability to take at least 10 steps. Use of assistive devices (e.g., walker or cane) is allowed.
• Anticipated survival of at least 3 years at the time of Screening, as judged by the Investigator.

You may not qualify if…

• Any condition that would interfere with the participant's ability to comply with study instructions, place the participant at unacceptable risk, and/or confound the interpretation of safety or efficacy data from the study, as judged by the Investigator.
• Diagnosis of neurological disorders, other than MSA.

Where it is running

• Barrow Neurological Institute — Phoenix, Arizona, United States
• UC San Diego Department of Neurosciences — La Jolla, California, United States
• UCLA Medical Center / Neurological Services — Los Angeles, California, United States
• Stanford University — Palo Alto, California, United States
• UCSF Memory and Aging Center — San Francisco, California, United States
• Rocky Mountain Movement Disorders Center — Englewood, Colorado, United States
• Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
• University of Florida — Gainesville, Florida, United States
• Mayo Clinic Florida — Jacksonville, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Chicago — Chicago, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• John Hopkins University — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Lahey Hospital & Medical Center — Burlington, Massachusetts, United States
• QUEST Research Institute — Farmington Hills, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Albany Medical College — Albany, New York, United States
• NYU School of Medicine, NYU Dysautonomia Center — New York, New York, United States
• Columbia University Medical Center, Neurological Institute — New York, New York, United States
• Pennsylvania State University Hershey Medical Center — Hershey, Pennsylvania, United States
• Parkinson's Disease and Movement Disorders Center at the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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