Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women

Recruiting now · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Infertility, Female, Perimenopausal Disorder, Menstrual Cycle Abnormal

In brief

Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.

Key facts

Study ID: NCT03951194
Run by: Genesis Athens Clinic
People needed: 100
Starts: 2019-06-13
Expected to finish: 2028-07-30
Last updated by the study team: 2026-07-08

Who can join

Age: 40 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Women ≥40 years of age, presenting with cycle irregularities while fulfilling at least one of the respective two criteria: more than seven days difference in menstrual cycle duration between two consecutive cycles OR, presence of a menstrual cycle duration over sixty days and progressive elevation of FSH levels.
Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
Willing to comply with study requirements

You may not qualify if…

Any pathological disorder related to reproductive system anatomy
Amenorrhea
Endometriosis
Adenomyosis
Fibroids and adhesions
Infections in reproductive system
Current or previous diagnosis of cancer in reproductive system
History of familiar cancer in reproductive system
Severe male factor infertility
Prior referral for PGT
Ovarian inaccessibility
Previous POI diagnosis -Endocrinological disorders (Hypothalamus-
Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
BMI>30 kg/m2 or BMI<18.5 kg/m2
Systematic autoimmune disorders

Where it is running

Genesis AC — Athens, Greece (enrolling)

Full record on ClinicalTrials.gov

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