Safety and Immunogenicity of V114 in Healthy Adults (V114-019/PNEU-AGE)

Completed · Phase 3

Conditions studied: Pneumococcal Infections

In brief

The purpose of this study is to 1) evaluate the safety and tolerability of V114 and 2) to compare the immune responses of the 15 serotypes contained in V114 with V114 versus Prevnar 13™. The primary hypotheses are that 1) V114 is noninferior to Prevnar 13™ as measured by the serotype specific opsonophagocytic activity (OPA) geometric mean titers (GMTs) for 13 shared serotypes at 30 days postvaccination and that 2) V114 is superior to Prevnar 13™ as measured by serotype-specific OPA GMTs for 2 unique serotypes in V114 at 30 days postvaccination.

Key facts

Study ID

NCT03950622

Run by

Merck Sharp & Dohme LLC

People needed

1205

Starts

2019-06-13

Expected to finish

2020-03-30

Last updated by the study team

2021-04-26

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participant has good health in the opinion of the investigator. Any underlying chronic condition must be documented to be in stable condition according to the investigator's judgment.
• Male or female ≥50 years of age at the time of signing the informed consent. (For Japan only: Is male or female ≥65 years of age at the time of signing the informed consent)
• Contraceptive use by women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
• Female participant is eligible to participate if she is not pregnant, not breastfeeding, and is not a woman of childbearing potential (WOCBP) OR a WOCBP who agrees to use agreed upon contraception during the treatment period and for at least 6 weeks after the last dose of study intervention.
• Provides written informed consent for the study. The participant may also provide consent for future biomedical research. However, the participant may participate in the main study without participating in future biomedical research.

You may not qualify if…

• History of invasive pneumococcal disease (IPD) (positive blood culture, positive cerebrospinal fluid culture, or positive culture at another sterile site) or known history of other culture-positive pneumococcal disease within 3 years of Visit 1 (Day 1).
• Known hypersensitivity to any component of pneumococcal polysaccharide vaccine, pneumococcal conjugate vaccine (PCV), or any diphtheria toxoid-containing vaccine.
• Known or suspected impairment of immunological function including, but not limited to, a history of congenital or acquired immunodeficiency, documented human immunodeficiency virus (HIV) infection, functional or anatomic asplenia, or history of autoimmune disease.
• Coagulation disorder contraindicating intramuscular (IM) vaccinations.
• Recent febrile illness (defined as oral or tympanic temperature ≥100.4°F [≥38.0°C] or axillary or temporal temperature ≥99.4°F [≥37.4°C]) or received antibiotic therapy for any acute illness occurring within 72 hours before receipt of study vaccine.
• History of malignancy ≤5 years prior to signing informed consent, except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer.
• A WOCBP who has a positive urine or serum pregnancy test before the first vaccination at Visit 1 (Day 1).
• Has received any pneumococcal vaccine or is expected to receive any pneumococcal vaccine during the study outside of the protocol.
• Has received systemic corticosteroids (prednisone equivalent of ≥20 mg/day) for ≥14 consecutive days and has not completed intervention at least 30 days before study entry.
• Has received systemic corticosteroids exceeding physiologic replacement doses (approximately 5 mg/day prednisone equivalent) within 14 days before vaccination. (Note: Topical, ophthalmic, intra-articular or soft-tissue [e.g., bursa, tendon steroid injections], and inhaled/nebulized steroids are permitted.)
• Is receiving immunosuppressive therapy, including chemotherapeutic agents used to treat cancer or other conditions, and interventions associated with organ or bone marrow transplantation, or autoimmune disease.
• Has received any non-live vaccine within the 14 days before receipt of any study vaccine or is scheduled to receive any non-live vaccine within 30 days following receipt of any study vaccine. (Exception: Inactivated influenza vaccine may be administered but must be given at least 7 days before receipt of any study vaccine or at least 15 days after receipt of any study vaccine.)
• Has received any live vaccine within 30 days before receipt of any study vaccine or is scheduled to receive any live vaccine within 30 days following receipt of any study vaccine.
• Has received a blood transfusion or blood products, including immunoglobulin, within the 6 months before receipt of study vaccine or is scheduled to receive a blood transfusion or blood product within 30 days of receipt of study vaccine. Autologous blood transfusions are not considered an exclusion criterion.
• Currently participating in or has participated in an interventional clinical study with an investigational compound or device within 2 months of participating in this current study.
• In the opinion of the investigator, has a history of clinically relevant drug or alcohol use that would interfere with participation in protocol-specified activities.
• History or current evidence of any condition, therapy, laboratory abnormality, or other circumstance that might expose the participant to risk by participating in the study, confound the results of the study, or interfere with the participant's participation for the full duration of the study.
• An immediate family member (e.g., spouse, parent/legal guardian, sibling, or child) who is investigational site or Sponsor staff directly involved with this study.

Where it is running

• Synexus ( Site 1001) — Mesa, Arizona, United States
• Artemis Institute for Clinical Research ( Site 1012) — San Diego, California, United States
• Indago Research & Health Center, Inc ( Site 1002) — Hialeah, Florida, United States
• Research Centers of America, LLC ( Site 1014) — Hollywood, Florida, United States
• Advanced Medical Research Institute ( Site 0117) — Miami, Florida, United States
• Lakes Research LLC ( Site 1005) — Miami Lakes, Florida, United States
• Alliance for Multispecialty Research, LLC ( Site 1008) — Newton, Kansas, United States
• Wake Research Clinical Research Center of Nevada, LLC ( Site 1010) — Las Vegas, Nevada, United States
• Rapid Medical Research, Inc. ( Site 1011) — Cleveland, Ohio, United States
• Diagnostics Research Group ( Site 1000) — San Antonio, Texas, United States
• Synexus ( Site 1009) — San Antonio, Texas, United States
• J Lewis Research Inc / Foothill Family Clinic ( Site 1013) — Salt Lake City, Utah, United States
• Charlottesville Medical Research Center, LLC ( Site 1003) — Charlottesville, Virginia, United States
• Health Research of Hampton Roads, Inc. ( Site 1007) — Newport News, Virginia, United States
• Colchester Research Group ( Site 2002) — Truro, Nova Scotia, Canada
• Milestone Research ( Site 2003) — London, Ontario, Canada
• Bluewater Clinical Research Group Inc ( Site 2004) — Sarnia, Ontario, Canada
• Manna Research Inc.. ( Site 2007) — Toronto, Ontario, Canada
• Dynamik Research ( Site 2000) — Pointe-Claire, Quebec, Canada
• Q & T Research Sherbrooke Inc. ( Site 2001) — Sherbrooke, Quebec, Canada
• P-One Clinic, Keikokai Medical Corp. ( Site 0400) — Hachiōji, Tokyo, Japan
• Souseikai PS Clinic ( Site 0402) — Fukuoka, Japan
• Souseikai Nishikumamoto Hospital ( Site 0404) — Kumamoto, Japan
• Medical Corporation Heishinkai OPHAC Hospital ( Site 0401) — Osaka, Japan
• Medical Corporation Houeikai Sekino Clinical Pharmacology Clinic ( Site 0403) — Tokyo, Japan

Full record on ClinicalTrials.gov

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