Measuring Plasticity in SFC/dACC Following Theta-Burst-Stimulation Using TMS

Completed · Not applicable

Conditions studied: Cognitive Control

In brief

This is a study to determine whether particular forms of brain-stimulation, applied to superior frontal cortex/preSMA can affect cognition and associated frontal theta oscillations. To perform this study, the investigators first measure brain activity and cognitive performance using "BrainE", a cognitive task platform that assesses cognition on sustained attention, response inhibition, working memory, interference processing and emotion processing assessments. Next, the investigators apply brain-stimulation over a mid-frontal region associated with these tasks (mid-line frontal activity overlying superior frontal cortex/pre-SMA area). Finally, human subjects perform the "BrainE" task assessments again immediately after the brain-stimulation. The investigators compare the effects of brain stimulation on average frontal activity evoked across the cognitive tasks, and on the cognitive performance averaged across tasks. The investigators primarily compare the effects of two types of brain-stimulation against each other: intermittent Theta-Burst Stimulation (a protocol designed to excite brain activity) and continuous Theta-Burst-Stimulation (a stimulation protocol designed to inhibit brain activity).

Key facts

Study ID

NCT03946059

Run by

University of California, San Diego

People needed

25

Starts

2019-04-30

Expected to finish

2019-10-30

Last updated by the study team

2021-03-09

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adequate decisional capacity to make a choice about participating in this research study.

You may not qualify if…

• No major active neurologic/psychiatric disease
• No contraindications for rTMS
• No behavioral/medical factors that increase risk of seizure

Where it is running

• Altman Clinical & Translational Research Institute — La Jolla, California, United States

Full record on ClinicalTrials.gov

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