Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis

In brief

In summary, the investigators propose to study elite Croatian breath-hold and SCUBA divers. The investigators will quantify breath-hold hypoxia- and SCUBA diving-induced pulmonary hypertension and right heart function to investigate the relationships between PFO and IPAVA blood flow. The investigators will use a placebo-controlled intervention (sildenafil) to reduce pulmonary arterial pressure in these subjects to examine the impact of the change in pressure (or absence of change) on the relationships determined above.

Key facts

Study ID

NCT03945643

Run by

University of Oregon

People needed

82

Starts

2019-07-01

Expected to finish

2023-07-31

Last updated by the study team

2023-08-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Reside in geographic location near Split, Croatia
• Elite breath hold divers
• Experienced SCUBA divers

You may not qualify if…

• Previous history of coronary artery disease
• Currently taking medication or herbal supplement for any heart or respiratory disease that cannot be ceased for 48 hours prior to testing
• Women who are pregnant or trying to become pregnant
• Previous history of any condition that would prevent the subject from performing a breath hold
• Taking sildenafil or products similar to sildenafil
• Taking Nitrates or other nitric oxide donors
• Control breath hold divers can't have previous breath hold diving experience

Where it is running

• Cardiorespiratory and Pulmonary Physiology Lab — Eugene, Oregon, United States

Full record on ClinicalTrials.gov

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