Efficacy and Tolerability Study of Two Dosing Regimens of CTP-543 in Adults With Alopecia Areata
Completed · Phase 2 · Has a placebo group
Conditions studied: Alopecia Areata
In brief
This study will evaluate the efficacy and tolerability of once-daily versus twice-daily dosing of CTP-543, in adult patients with chronic, moderate to severe alopecia areata.
Key facts
- Study ID
- NCT03941548
- Run by
- Concert Pharmaceuticals
- People needed
- 66
- Starts
- 2019-05-24
- Expected to finish
- 2020-04-10
- Last updated by the study team
- 2023-04-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical presentation compatible with alopecia areata with a current episode lasting at least 6 months and not exceeding 10 years at the time of Screening. Total disease duration greater than 10 years is permitted.
- At least 50% scalp hair loss, as defined by a Severity of Alopecia Tool (SALT) score ≥50, at Screening and Baseline.
You may not qualify if…
- Active scalp inflammation, psoriasis, or seborrheic dermatitis requiring topical treatment to the scalp, significant trauma to the scalp, or untreated actinic keratosis on the scalp.
- Treatment with systemic immunosuppressive medications within 3 months of screening or during the study, or biologics within 6 months of screening or during the study.
- Clinical lab results outside the normal range.
Where it is running
- Colorado Center for Dermatology and Skin Surgery — Centennial, Colorado, United States
- ForCare Clinical Research — Tampa, Florida, United States
- The Indiana Clinical Trials Center, PC — Plainfield, Indiana, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Austin Institute for Clinical Research, Inc. — Pflugerville, Texas, United States
- SimcoDerm Medical and Surgical Dermatology Center — Barrie, Ontario, Canada
- Guelph Dermatology Research — Guelph, Ontario, Canada
- Dr Wei Jing Loo Medicine Professional Corporation — London, Ontario, Canada
- Lynderm Research Inc. — Markham, Ontario, Canada
- The Centre for Clinical Trials — Oakville, Ontario, Canada
- Research Toronto — Toronto, Ontario, Canada
- Innovaderm Research Inc. — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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