Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer
Recruiting now
Conditions studied: Colorectal Cancer Metastatic
In brief
In this study the characteristics and alterations of the gut microbiome during chemotherapy for metastasized or irresectable CRC are studied, as well as the relation between the gut microbiome and the effects of chemotherapy.
Key facts
- Study ID
- NCT03941080
- Run by
- University Medical Center Groningen
- People needed
- 300
- Starts
- 2020-09-09
- Expected to finish
- 2026-01-01
- Last updated by the study team
- 2025-01-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Patients with histologically confirmed CRC with an indication for palliative systemic anti-tumor therapy (ANY combination of chemotherapy with/without anti-VEGF of anti-EGFR therapy)
- Measurable disease according to RECIST v1.1.
- Stored pathological specimens available
- Life expectancy ≥ 12 weeks
- Signed Informed Consent Form
- Ability to comply with protocol
You may not qualify if…
- Previous (neo)adjuvant chemotherapy < 6 months
- Previous radiotherapy on the small or large intestine < 1month
- Previous surgery of the small or large intestine < 1 month
- Uncontrolled inflammatory bowel disease
- Participation in a study with a potential effect on the gut microbiome
Where it is running
- Wilhelmina Ziekenhuis — Assen, Netherlands (enrolling)
- Ziekenhuis Nij Smellinghe — Drachten, Netherlands (enrolling)
- Treant Zorggroep — Emmen, Netherlands (enrolling)
- Medisch Spectrum Twente — Enschede, Netherlands (enrolling)
- University Medical Center Groningen — Groningen, Netherlands (enrolling)
- Martini Ziekenhuis — Groningen, Netherlands (enrolling)
- Tjongerschans Ziekenhuis — Heerenveen, Netherlands (enrolling)
- Medisch Centrum Leeuwarden — Leeuwarden, Netherlands (enrolling)
- Ommelander Ziekenhuis Groep — Scheemda, Netherlands (enrolling)
- Antonius Zorggroep — Sneek, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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