CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

Completed

Conditions studied: Alzheimer's Disease, Brain Diseases, Central Nervous System Diseases, Delirium, Dementia, Amnestic, Cognitive Disorders, Dementia, Mental Disorders, Nervous System Diseases, Neurodegenerative Diseases, Tauopathies

In brief

Alzheimer's disease (AD) is the most common cause of dementia and currently has no disease modifying treatments or simple accurate diagnostic tests. The goal of this project is to study how tau (a protein thought to cause AD) is made, transported and cleared in the human body. Better understanding of these processes may lead to improved understanding of AD, earlier diagnosis and a way to evaluate treatment.

Key facts

Study ID

NCT03938870

Run by

Washington University School of Medicine

People needed

96

Starts

2015-08-18

Expected to finish

2023-07-06

Last updated by the study team

2024-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males or females of any race aged 18 or older
• No evidence of a neurologic disorder or traumatic head injury by history or examination
• Able to take food and drink by mouth safely
• Participants must be able to provide informed consent
• Absence of exclusion criteria

You may not qualify if…

• Requires tube feeding for nutrition and/or hydration
• Already on a special diet (e.g. Gluten free)
• History of bleeding disorder
• Allergy to Lidocaine
• Pregnancy
• Any contraindication for lumbar puncture e.g. blood thinners

Where it is running

• Washington University in Saint Louis — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.