NGS for Non-unions

Status unconfirmed

Conditions studied: Nonunion of Fracture

In brief

The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures. The study aims to compare the results of genetic testing known as NGS to standardized clinical laboratory tests for diagnosing infections to see if NGS may be a better diagnostic tool.

Key facts

Study ID

NCT03937310

Run by

Rothman Institute Orthopaedics

People needed

120

Starts

2019-01-03

Expected to finish

2022-02-03

Last updated by the study team

2019-05-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Exclusion:
• Pathological fractures at index injury
• Patients on antibiotic therapy <2 weeks prior to surgery
• INCLUSION/ EXCLUSION CRITERIA FOR CONTROL GROUP:
• Inclusion:
• Patients undergoing surgical intervention for nonunion following a traumatic closed long bone fractures (femur shaft, tibia, humerus)
• >18 years old and able to provide informed consent
• Exclusion:
• Pathological fractures at index injury
• Patients on antibiotic therapy <2 weeks prior to surgery

Where it is running

• Rothman Institute — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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