Efficacy and Safety Trial of ADU-S100 and Pembrolizumab in Head and Neck Cancer
Stopped early · Phase 2
Conditions studied: Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
In brief
ADU-CL-20 is an open-label, multicenter Phase 2 clinical trial to evaluate the efficacy and safety of intratumoral ADU-S100 (also referred to as MIW815) administered with pembrolizumab in the first-line setting. The population will consist of adults with PD-L1 positive recurrent or metastatic HNSCC.
Key facts
- Study ID
- NCT03937141
- Run by
- Chinook Therapeutics, Inc. (formerly Aduro)
- People needed
- 16
- Starts
- 2019-08-26
- Expected to finish
- 2021-06-10
- Last updated by the study team
- 2022-01-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histological or cytological confirmation of recurrent or metastatic HNSCC
- Measurable disease as defined by RECIST v1.1
- PD-L1 positive
You may not qualify if…
- Diagnosis of recurrent or metastatic carcinoma of the nasopharynx, squamous cell carcinoma of unknown primary histology; or salivary gland or non-squamous histologies (e.g. mucosal melanoma)
- Disease amenable to local therapy with curative intent (surgery or radiation therapy with or without chemotherapy)
- Prior systemic anti-cancer therapy (use of chemotherapeutic agents, targeted small molecules, immunotherapy, or monoclonal antibodies) for the treatment of recurrent or metastatic HNSCC
Where it is running
- University of Alabama Comprehensive Cancer Center — Birmingham, Alabama, United States
- University of Arizona Cancer Center — Tucson, Arizona, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Yale University Cancer Center — New Haven, Connecticut, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Emory University Hospital — Atlanta, Georgia, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- University of Kansas — Westwood, Kansas, United States
- James Graham Brown Cancer Center — Louisville, Kentucky, United States
- University of Maryland, Greenebaum Comprehensive Cancer Center — Baltimore, Maryland, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Regions Cancer Care Center — Saint Paul, Minnesota, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- University Pittsburgh Medical Center Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
- MUSC Hollings Cancer Center — Charleston, South Carolina, United States
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
- Baylor University Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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