A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants

Completed · Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to assess the effect of multiple dose administrations of Omeprazole on the pharmacokinetics of BMS-986205.

Key facts

Study ID

NCT03936374

Run by

Bristol-Myers Squibb

People needed

16

Starts

2019-05-08

Expected to finish

2019-07-20

Last updated by the study team

2019-09-23

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Health male and female participants (not of childbearing potential) as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations
• normal renal function at screening as evidenced by an estimated glomerular filtration rate (GFR) greater than or equal to (>=) 80 milliliter per minute per 1.73 meter square (mL/min/1.73 m\^2)
• Body mass index (BMI) of 18.0 kilogram per meter square (kg/m\^2) to 32.0 kg/m\^2
• Women participants must have documented proof that they are not of childbearing potential

You may not qualify if…

• Women who are of childbearing potential or breastfeeding
• Active tuberculosis (TB) requiring treatment or documented latent TB within the previous 3 years
• Concomitant use of strong inhibitors or strong inducers of CYP3A4
• Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, ECG, or clinical laboratory determinations beyond what is consistent with the target population

Where it is running

• PPD Phase I Clinic — Austin, Texas, United States

Full record on ClinicalTrials.gov

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