Determination of Pre-Absorptive Dissociation of Zinc From a Zinc Amino Acid Complex in Healthy Men
Completed · Not applicable
Conditions studied: Fractional Zinc Absorption
In brief
Zinc may be absorbed from diet via zinc transporter mediated pathways, or, when coupled with amino acids, via amino acid transporter pathways. When zinc is coupled with amino acids in diet, it may dissociate from those amino acids in the acidic environment of the stomach prior to entering the small intestine. An experimentally-determined value for any pre-absorptive dissociation of zinc from a zinc amino acid complex (ZnAA) is necessary for the accurate compartmental modeling of zinc metabolism when provided as ZnAA compared with ionic zinc, which the investigators will perform in a future study. The current study will allow us to determine the dissociation of zinc from ZnAA, while serving as a pilot test of a novel technique to determine for the first time an individual's zinc transport kinetics.
Key facts
- Study ID
- NCT03934346
- Run by
- UCSF Benioff Children's Hospital Oakland
- People needed
- 13
- Starts
- 2019-06-10
- Expected to finish
- 2019-12-16
- Last updated by the study team
- 2020-01-22
Who can join
Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Apparently healthy men
- Body mass index between 18 and 30 kg/m2
- Willing to eat only the foods provided by the study for a 2 week period
You may not qualify if…
- Those reporting any chronic or acute diseases, food allergies, smoking or alcohol abuse
- Use of illicit drugs; regular consumption of medications, micronutrient supplements, or both
- Vegetarians, or those unable to eat meat, are also excluded since the foods for the study contain meat
- Unable to refrain from taking medications during the study period
Where it is running
- Children's Hospital and Research Center Oakland — Oakland, California, United States
Full record on ClinicalTrials.gov
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