Gene Expression Changes In Young and Geriatric Skin

Recruiting now · Early Phase 1

Conditions studied: UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging

In brief

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Key facts

Study ID
NCT03932162
Run by
Wright State University
People needed
24
Starts
2019-09-06
Expected to finish
2025-12-01
Last updated by the study team
2025-02-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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