Inorganic Nitrate and OSA

Completed · Not applicable · Has a placebo group

Conditions studied: Obstructive Sleep Apnea

In brief

The main purpose of this study is to determine if acute beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea. All subjects will consume low-dose (BRL), higher-dose (BRH), and placebo (BRP) beetroot juice randomly on three independent study visits. Beetroot juice also improves blood flow thus, the investigators will also measure blood flow to the carotid chemoreceptors.

Key facts

Study ID

NCT03930563

Run by

University of Iowa

People needed

21

Starts

2019-06-12

Expected to finish

2020-03-06

Last updated by the study team

2021-04-27

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• OSA group: patients recently diagnosed with mild-to-moderate OSA
• Control group: healthy individuals

You may not qualify if…

• Diagnosis of heart disease
• Diagnosis of diabetes
• Diagnosis of any autonomic disorders
• Diagnosis of kidney disease
• Diagnosis of central sleep apnea
• Regular physical activity exceeding 30 minutes 3 days/week
• A body mass index ≥40 kg/m2
• Current or former use of a continuous positive airway pressure machine
• Current tobacco use
• Currently prescribed hormone replacement therapy

Where it is running

• Medical Education Building — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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