Predicting Treatment Response to Exposure Therapy Using Carbon Dioxide

Completed · Not applicable

Conditions studied: Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia

In brief

Anxiety disorders affect over a quarter of the population, yet very little is known about the variables that predict treatment outcome. The planned study explores whether a patient's response to a physiological test involving inhalation of carbon dioxide predicts their response to exposure therapy.

Key facts

Study ID

NCT03925987

Run by

Laureate Institute for Brain Research, Inc.

People needed

70

Starts

2018-06-07

Expected to finish

2020-07-31

Last updated by the study team

2023-12-15

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• DSM-V diagnosis of an Anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia)
• Anxiety Sensitivity Index (ASI-3) total score > 29
• Overall Anxiety Severity and Impairment Scale (OASIS) score > 8
• Between 18-55 years of age
• Subject must be "treatment-seeking" and willing to enroll in the 10-week group-based Exposure Therapy

You may not qualify if…

• Comorbid Bipolar Disorder, Schizophrenia, Anorexia or Bulimia Nervosa, or Obsessive-Compulsive Disorder
• Current Substance Use Disorder > moderate (within the past 6 months)
• Currently taking a psychotropic medication
• Currently receiving psychotherapy/counseling for anxiety
• Currently being treated as an inpatient
• Active suicidal ideation with intent or plan
• History of neurological, cardiovascular or respiratory problems (e.g., asthma, severe brain injury)

Where it is running

• Laureate Institute for Brain Research — Tulsa, Oklahoma, United States

Full record on ClinicalTrials.gov

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