A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis

Completed · Phase 4

Conditions studied: Cystic Fibrosis

In brief

Part 1 is a study to demonstrate that Creon (pancrelipase) delayed release (DR) capsules manufactured with a modernized process (MP) is non-inferior to currently marketed pancrelipase DR capsules in participants with exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF), as measured by coefficient of fat absorption (CFA). Part 2 is a study to demonstrate that Creon (pancrelipase) manufactured with an alternate active pharmaceutical ingredient site (AAPIS) is non-inferior to currently marketed active control (Creon®) in participants with EPI due to CF, as measured by CFA. Safety is evaluated in each part.

Key facts

Study ID

NCT03924947

Run by

AbbVie

People needed

36

Starts

2019-10-23

Expected to finish

2022-07-11

Last updated by the study team

2023-09-28

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant has a documented diagnosis of Cystic Fibrosis (CF) confirmed by:
• a sweat chloride test >= 60 mmol/L, and/or
• documented CF-causing cystic fibrosis transmembrane conductance regulator (CFTR) mutations and clinical features of CF.
• Participant has diagnosis of moderate to severe Exocrine Pancreatic Insufficiency (EPI), as determined by Fecal Elastase 1 (FE-1) < 15 μg/g at screening.
• Participant has EPI that is currently clinically controlled (no clinically overt steatorrhea or diarrhea) under treatment with a commercially available Pancreatic Enzyme Replacement Therapy (PERT), on an individually established dose regimen for more than 3 months prior to Screening, with a daily dose not exceeding 4,000 Lipase Units (LU)/g fat/day or 10,000 LU/kg/day.
• Participant is available for two (if participating in one of the parts) or four (if participating in both parts) hospitalization/confinement periods of 6 to 8 days each during the expected study window.
• Participant is able to consume a diet with 100 g fat/day, a minimum of 1 g/kg of protein/day and normal to low fiber content.

You may not qualify if…

• BMI percentile for age less than 10% in participants less than 18 years of age.
• Participant has a history of any of the following gastrointestinal disorders (acute pancreatitis within 6 months prior to Visit 2, chronic pancreatitis, fibrosing colonopathy, distal intestinal obstruction syndrome (DIOS) within 6 months prior to Visit 2, C. difficile infection within 6 months prior to Visit 2, celiac disease, gastric bypass or partial/total gastrectomy, Crohn's disease or other inflammatory bowel disease, small bowel surgery (other than minor resection due to meconium ileus without resultant malabsorption syndrome), or any type of malignancy involving the digestive tract in the last 5 years).
• Participant has a history of any clinically significant endocrine, respiratory (except mild asthma or CF related lung disease), neurological, cardiac, renal, hepatic (including Hepatitis B or C), hematologic or psychiatric disease or disorder, or any other uncontrolled medical illness which might limit participation in or completion of the study.
• Participant requires concomitant treatment with any medication not allowed by the protocol or a prohibited medication is expected to be needed during the study.
• Participant is currently receiving nutritional supplementation via tube feeding (nasogastric, gastrostomy, jejunostomy).
• Participant has clinically significant (as per Investigator's judgment) abnormalities in clinical chemistry, hematology, or urinalysis (excluding findings that are associated with CF) such as aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels >= 3 times the upper limit of normal values, or clinically significant (investigator opinion) elevation of uric acid.

Where it is running

• University of Southern California /ID# 164571 — Los Angeles, California, United States
• Landon Pediatric Foundation /ID# 215411 — Ventura, California, United States
• Nemours Children's Health System /ID# 164553 — Jacksonville, Florida, United States
• Central FL Pulmonary Orlando /ID# 164558 — Orlando, Florida, United States
• The Cystic Fibrosis Institute /ID# 210757 — Northfield, Illinois, United States
• University of Iowa Hospitals and Clinics /ID# 164551 — Iowa City, Iowa, United States
• Via Christi Research /ID# 214266 — Wichita, Kansas, United States
• UH Cleveland Medical Center /ID# 206095 — Cleveland, Ohio, United States
• Cleveland Clinic Main Campus /ID# 212853 — Cleveland, Ohio, United States
• Nationwide Children's Hospital /ID# 225628 — Columbus, Ohio, United States
• Children's Hospital of Philadelphia - Main /ID# 208114 — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center /ID# 213434 — Nashville, Tennessee, United States
• Virginia Commonwealth University Medical Center Main Hospital /ID# 164574 — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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