Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

Recruiting now

Conditions studied: Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence

In brief

The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution and infants at risk of significant neonatal abstinence syndrome (NAS).

Key facts

Study ID

NCT03923374

Run by

Senthil Sadhasivam

People needed

600

Starts

2018-09-15

Expected to finish

2026-12-30

Last updated by the study team

2025-12-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age greater 18 years
• Currently taking Buprenorphine for Opioid Use Disorder and enrolled in a prenatal opioid maintenance program in the antenatal clinic at IU Health University Hospital.
• Pregnant with single baby
• Planned delivery at Methodist, University or Riley Hospital

You may not qualify if…

• Serious maternal medical illness as deemed by study physician or investigator.
• Known or suspected major fetal/neonatal congenital abnormalities.

Where it is running

• UPMC Children's Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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