SMARTfit Training for Parkinson's Disease

Stopped early · Not applicable

Conditions studied: Parkinson Disease, Exercise Training, Cognitive Change

In brief

This pilot study aims to investigate the effects of 8-week SMARTfit training versus conventional physical training on motor function, cognition and brain functional connectivity in individuals with PD. The investigators hypothesize that clinical and physical performance will improve after SMARTfit training more than after conventional physical training.

Key facts

Study ID

NCT03921359

Run by

University of Southern California

People needed

9

Starts

2018-05-19

Expected to finish

2020-03-16

Last updated by the study team

2020-07-07

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 50-85 years of age
• Diagnosis of idiopathic Parkinson's disease using the UK Brain Bank criteria (as determined by the study movement disorders neurologist) with Hoehn and Yahr stage 1-2
• No contraindications to exercise including untreated cardiovascular disease or stroke
• Medically stable and optimized on their medications
• Able to ambulate independently with or without device
• No other neurologic, neuromuscular, or orthopedic disease
• No serious cognitive deficits and able to participate in the informed consent process
• With medical clearance from primary care physician to participate in the physical therapy intervention
• No contraindications for MRI

You may not qualify if…

• Severe cardiac disease (New York Heart Association classification II-IV)
• Systolic blood pressure reduction of greater than 20 mmHg with standing
• A history of poorly controlled or brittle diabetes
• A history of lower limb amputation
• Been prescribed any new dopamine replacement medications or new mood stabilizer medications.
• Presence of a lower limb non-healing ulcer
• Montreal cognitive assessment score of less than 21
• The presence of any medical condition which the investigator believes might present an unacceptable health risk to the subject should they participate in the study
• Electrically, magnetically, or mechanically activated implant (such as cardiac pacemakers or intracerebral vascular clip)
• Metal in any part of the body including metal injury to the eye
• History of brain lesions (such as stroke), seizures, or unexplained spells of loss of consciousness
• Pregnant or breast-feeding
• With other neurologic, neuromuscular, or orthopedic disease that would interfere with ability to participate in exercise training
• Currently participating in other studies

Where it is running

• USC Center for Neurorestoration — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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