An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Non-small Cell Lung Cancer
In brief
This is an open-label, multicenter, non-randomized, Phase 2 study to determine the safety, tolerability and efficacy of encorafenib given in combination with binimetinib in patients with BRAFV600E-mutant metastatic non-small cell lung cancer (NSCLC). Patients who are either treatment-naïve, OR who have received 1) first-line treatment with standard platinum-based chemotherapy, OR 2) first-line treatment with an anti-programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitor given alone or in combination with platinum-based chemotherapy will be enrolled.
Key facts
- Study ID
- NCT03915951
- Run by
- Pfizer
- People needed
- 98
- Starts
- 2019-06-04
- Expected to finish
- 2025-10-03
- Last updated by the study team
- 2026-03-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yuma Regional Medical Center Ophthalmology — Yuma, Arizona, United States
- Yuma Regional Medical Center — Yuma, Arizona, United States
- UCLA Hematology/Oncology — Los Angeles, California, United States
- UCLA Stein Eye Center Santa Monica (OPH) — Santa Monica, California, United States
- UCLA Hematology/Oncology — Santa Monica, California, United States
- Florida Cancer Specialist — Altamonte Springs, Florida, United States
- Florida Cancer Specialists — Bonita Springs, Florida, United States
- Florida Cancer Specialist — Brandon, Florida, United States
- Florida Cancer Specialists — Cape Coral, Florida, United States
- Florida Cancer Specialist — Clearwater, Florida, United States
- Florida Cancer Specialists — Fleming Island, Florida, United States
- Florida Cancer Specialists — Fort Myers, Florida, United States
- Florida Cancer Specialists — Fort Myers, Florida, United States
- Florida Cancer Specialists — Fort Myers, Florida, United States
- Florida Cancer Specialists — Fort Myers, Florida, United States
- Florida Cancer Specialist — Gainesville, Florida, United States
- Florida Cancer Specialists — Largo, Florida, United States
- Florida Cancer Specialist — Lecanto, Florida, United States
- Florida Cancer Specialists — Naples, Florida, United States
- Florida Cancer Specialist — Ocala, Florida, United States
- Florida Cancer Specialist — Orange City, Florida, United States
- Florida Cancer Specialist — Orlando, Florida, United States
- Florida Cancer Specialists — Port Charlotte, Florida, United States
- Florida Cancer Specialists — Sarasota, Florida, United States
- Yuma Regional Medical Center Cancer Center — Yuma, Arizona, United States
Full record on ClinicalTrials.gov
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