Sleep Disordered Breathing and Alzheimer's Disease Biomarkers in Normal Aging and Mild Cognitive Impairment

Completed

Conditions studied: Sleep Disorder

In brief

The purpose of this study is to determine the sleep patterns of subjects with or without sleep disturbances (insomnia, sleep apnea) and compare these findings with their previous FDG/PIB PET, structural MRI and brain blood flow scams performed during their participation in the Following studies 'Alzheimer's Disease Core Center (ADCC) Clinical Evaluation' (IRB: 2942), MRI Progression Markers of Cognitive Decline in the Elderly' (IRB:09-0586), or 'Imaging Neuro inflammation in Alzheimer's Disease with \[11C\] Arachidonic Acid (AA) and PET'(IRB: 10-00442).

Key facts

Study ID

NCT03912571

Run by

NYU Langone Health

People needed

28

Starts

2011-11-13

Expected to finish

2019-09-01

Last updated by the study team

2021-09-05

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All subjects will have participated in prior CBH studies and have agreed to an FDG, PIB and MRI scans.

You may not qualify if…

• Diagnosis of sleep apnea and under treatment with a continuous positive airway pressure (CPAP) machine.
• Active depressive episode during the evaluation with a Geriatric Depression Scale score >7 and/or a Clinical Global Impression scale for depression score >4.
• Moderate Cognitive decline (GDS >3).
• Severe primary or secondary insomnia except insomnia due to SDB.

Where it is running

• NYU Langone Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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