A Study to Evaluate the Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis
Completed · Phase 2 · Has a placebo group
Conditions studied: Cystic Fibrosis
In brief
The purpose of this study is to evaluate the safety, tolerability and efficacy of VX-121 combination therapy in subjects with cystic fibrosis (CF).
Key facts
- Study ID
- NCT03912233
- Run by
- Vertex Pharmaceuticals Incorporated
- People needed
- 87
- Starts
- 2019-04-30
- Expected to finish
- 2019-12-10
- Last updated by the study team
- 2023-04-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Keck Medical Center of University of Southern California — Los Angeles, California, United States
- Kaiser Permanente — Oakland, California, United States
- University of Kentucky. — Lexington, Kentucky, United States
- Tulane Medical Center — New Orleans, Louisiana, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Columbia University Medical Center — New York, New York, United States
- Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States
- Nationwide Children's Hospital — Columbus, Ohio, United States
- Santiago Reyes, M.D. — Oklahoma City, Oklahoma, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
- Charite Paediatric Pulmonology Department — Berlin, Germany
- Ruhrlandklinik Westdeutsches Lungenzentrum am Klinikum Essen — Essen, Germany
- Pneumologisches Studienzentrum Muenchen-West — München, Germany
- Academic Medical Center — Amsterdam, Netherlands
- University Medical Center, Utrecht, Department of Pulmonology and Tuberculosis — Heidelberglaan, Netherlands
- UMC St. Radboud — Nijmegen, Netherlands
- Erasmus Medical Center — Rotterdam, Netherlands
- HagaZiekenhuis van den Haag — The Hague, Netherlands
- Hospital de Santa Maria — Lisbon, Portugal
- University Hospitals Birmingham NHS Foundation Trust — Birmingham, United Kingdom
- Royal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital — London, United Kingdom
- Wythenshawe Hospital — Manchester, United Kingdom
- The Newcastle upon Tyne Hospitals NHS Foundation Trust, The Royal Victoria Infirmary — Newcastle upon Tyne, United Kingdom
Full record on ClinicalTrials.gov
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