A Study of Photon and Proton Chemoradiotherapy as Definitive or Neoadjuvant Therapy in Non-Metastatic Pancreatic Cancer
Running, not enrolling
Conditions studied: Pancreatic Cancer
In brief
This study will observe side effects for patients who receive a 3-week course of radiation and chemotherapy for pancreas cancer. Blood samples will be collected before and after treatment to assess pancreas cancer DNA levels and its impact on outcomes.
Key facts
- Study ID
- NCT03902600
- Run by
- Mayo Clinic
- People needed
- 103
- Starts
- 2018-05-10
- Expected to finish
- 2026-08-31
- Last updated by the study team
- 2026-01-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Presence of non-regional nodal involvement or distant metastatic disease (M1)
- Prior RT to the thorax, abdomen, or pelvis
- History of prior malignancy < 2 years of enrollment, except non-melanotic skin cancer or carcinoma-in-situ of the cervix
- Immunocompromised patients and patients known to be HIV positive and not currently receiving antiretroviral therapy.
- Note: Patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for this trial.
- Receiving any investigational agent concurrent with CRT which would be considered as a treatment for the primary neoplasm.
- Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects:
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate contraception
- Co-morbid systemic or psychiatric illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Where it is running
- Mayo Clinic in Arizona — Scottsdale, Arizona, United States
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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