Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

Recruiting now · Not applicable

Conditions studied: Mechanical Ventilation Complication

In brief

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

Key facts

Study ID

NCT03901924

Run by

University of Chicago

People needed

468

Starts

2019-03-04

Expected to finish

2027-05-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• subjects > 18 years of age that have been intubated and mechanically ventilated for < 36 hours at the time of screening will be eligible for enrollment

You may not qualify if…

• pregnancy
• cardiopulmonary arrest
• history of diaphragmatic paralysis or neuromuscular disease
• chronic obstructive pulmonary disease (COPD) or asthma exacerbation with evidence of auto-PEEPing requiring intubation
• neuromuscular blockade
• expectation to be liberated from ventilator in < 24 hours
• history of mechanical ventilation in the last 6 months
• presence of tracheostomy
• high cervical spine injury

Where it is running

• The University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)
• University of Iowa — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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