Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet

Completed · Not applicable

Conditions studied: Cholesterol Metabolism, Ketone Metabolism

In brief

The purpose of this study is to understand how the reduction in dietary carbohydrates in a very-low carbohydrate ketogenic diet impacts the synthesis of cholesterol, fatty acid, and ketones, and the turnover rate of VLDL and chylomicron particles.

Key facts

Study ID

NCT03901014

Run by

Touro University, California

People needed

4

Starts

2019-03-29

Expected to finish

2019-04-18

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male
• 18-50 years old

You may not qualify if…

• Use of nicotine products
• Has dietary restrictions
• Lactose intolerance
• History of GI disorders, diabetes, liver, kidney, or thyroid disorders
• Taking hypolipidemic, anti-diabetic, anti-hypertensive, or anti-depression medication
• Screening plasma triglyceride < 50mg/dl or >500mg/dl
• Screening glucose > 125mg/dl
• Screening total and LDL-Cholesterol over 95th %tile for age and sex
• BP > 160/95 mmHg
• Weight loss/gain > 5% in the previous 3 months (self-reported)

Where it is running

• Touro University California — Vallejo, California, United States

Full record on ClinicalTrials.gov

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