An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
Running, not enrolling · Phase 2
Conditions studied: Melanoma
In brief
The purpose of this study is to assess whether postoperative adjuvant therapy with mRNA-4157 and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma and a high risk of recurrence.
Key facts
- Study ID
- NCT03897881
- Run by
- ModernaTX, Inc.
- People needed
- 267
- Starts
- 2019-07-18
- Expected to finish
- 2032-11-30
- Last updated by the study team
- 2025-12-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Arizona — Tucson, Arizona, United States
- California Pacific Medical Center Research Institute -CPMCRI — San Francisco, California, United States
- Angeles Clinic and Research Institute — Santa Monica, California, United States
- University of Colorado Cancer Center — Aurora, Colorado, United States
- Smilow Cancer Center at Yale New Haven Hospital — New Haven, Connecticut, United States
- Lombardi Cancer Center — Washington D.C., District of Columbia, United States
- Orlando Health UF Health Cancer Center — Orlando, Florida, United States
- Northside Hospital — Atlanta, Georgia, United States
- UPMC Hillman Cancer Center — Chicago, Illinois, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- NYU Langone Medical Center — New York, New York, United States
- Providence Cancer Institute — Portland, Oregon, United States
- Sarah Cannon Cancer Center — Nashville, Tennessee, United States
- Texas Oncology PA — Dallas, Texas, United States
- Melanoma Institute Australia — North Sydney, New South Wales, Australia
- Westmead Hospital — Westmead, New South Wales, Australia
- Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
- Affinity Clinical Research — Murdoch, Western Australia, Australia
- One Clinical Research Perth — Murdoch, Western Australia, Australia
- St John of God Hospital Subiaco — Subiaco, Western Australia, Australia
Full record on ClinicalTrials.gov
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