Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

Completed · Phase 4

Conditions studied: Pediatrics, Anesthesia, Vasospasm

In brief

The purpose of this study is to compare intraoperative papaverine plus heparin to heparin alone for prevention of arterial spasm and maintenance of patency of peripheral arterial catheters during surgery in pediatric patients. The hypothesis is that periodic, intraoperative small-volume boluses of diluted papaverine plus heparin in peripheral arterial catheters of pediatric patients will prevent arterial spasm and help maintain patency of arterial catheters during general anesthesia.

Key facts

Study ID

NCT03894904

Run by

The University of Texas Health Science Center, Houston

People needed

100

Starts

2019-04-01

Expected to finish

2020-10-10

Last updated by the study team

2022-10-27

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients age 0-17 years who would require elective placements of arterial catheters based on patients clinical complexity (ex. congenital heart disease) or based on the type of surgery (ex. open heart surgery).

You may not qualify if…

• Patients with a history of significant liver dysfunction.
• Patients undergoing liver transplants.
• Patients with Grade 2 or more of intraventricular hemorrhage.
• All preterm patients with a gestational age less than 37 weeks at the time of surgery.

Where it is running

• UT Health — Houston, Texas, United States

Full record on ClinicalTrials.gov

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