Brief Stresses Experimental Study

Stopped early · Phase 1 · Has a placebo group

Conditions studied: DNA Damage, Psychological Stress

In brief

The goal of this study is to examine the impact of psychological stress on DNA integrity by conducting an experiment under controlled conditions with healthy volunteers to directly test the extent to which acute stress increases DNA damage, while simultaneously testing the blocking effects of pre-treatment with propranolol, and exploring key hypothesized mediators and moderators of the severity of the DNA damage.

Key facts

Study ID

NCT03893617

Run by

Dana Bovbjerg

People needed

239

Starts

2017-10-05

Expected to finish

2022-01-27

Last updated by the study team

2023-07-18

Who can join

Age: 20 and older, up to 59. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 20-59
• Weigh at least 110 pounds
• Fasting blood sugar below 150 mg/dL, or random blood sugar below 200 mg/dL
• Thyroid stimulating hormone level between 0.25 mU/L and 6.0 mU/L
• Resting blood pressure below 160/100 mm Hg
• If female, have either regular menstrual periods (21-35 days) or are post-menopausal

You may not qualify if…

• Use of illicit drugs or nicotine-containing products other than cigarettes in the past month
• Current alcohol abuse
• Diagnosed with any of the following: cancer (other than basal cell skin cancer), chronic obstructive pulmonary disorder (COPD), multiple sclerosis (MS), severe traumatic brain injury, hypertension (high blood pressure), coronary artery disease, congestive heart failure, or other serious heart disease
• Current diabetes, asthma, depression, bipolar disorder, anxiety, or schizophrenia
• If female, pregnancy or breastfeeding within the past 3 months
• If female, taking any medications that prevent monthly menstrual cycles (e.g., birth control shot, IUD, "seasonal" birth control)
• Resting systolic blood pressure of < 90 mm Hg or resting pulse < 50 beats per minute

Where it is running

• UPMC Shadyside — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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