Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"

Recruiting now · Not applicable

Conditions studied: Dementia, Alzheimer Type

In brief

The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. There are three main objectives of the protocol: 1) to determine if a physical activity intervention tailored to older African American adults is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to determine if a physical activity intervention tailored to older African American adults is effective in modifying brain function and structure associated with Alzheimer's Disease, and 3) to determine if a physical activity promotion intervention tailored to African American adults is effective at enhancing physiological parameters. The primary endpoints for the study are episodic memory and executive functioning. The secondary outcomes include anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical activity, circulating hormones, and telomere length.

Key facts

Study ID

NCT03890861

Run by

Pennington Biomedical Research Center

People needed

125

Starts

2019-08-09

Expected to finish

2026-11-01

Last updated by the study team

2024-11-25

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• self- identify as African American
• 60 years and older
• willing to accept randomization
• willing to attend group sessions
• lacking plans to move during the study period
• free of conditions that would make regular exercise unsafe (e.g. uncontrolled asthma, severe sickle cell disease, etc.)
• not engaged in regular physical activity
• Short Physical Performance Battery score >/= 4
• physically capable of exercise,

You may not qualify if…

• cognitive impairment that would interfere with participating in group interactions
• unwilling to give written informed consent
• inability to attend group sessions
• conditions that prevent regular exercise
• conditions that the medical or principal investigator determine to warrant exclusion

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States (enrolling)

Full record on ClinicalTrials.gov

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