The Influence of Non-Caloric Artificial Sweeteners on Youth With Type 1 Diabetes

Completed

Conditions studied: Type 1 Diabetes Mellitus

In brief

The investigators aim to further the understanding of environmental factors that may underlie variations in body composition seen in youth with Type 1 diabetes (T1D). Non-caloric artificial sweeteners, broadly consumed in many individuals with T1D, are a modifiable dietary factor that may be associated with negative health outcomes, particularly those relevant to the future risk of diabetes-related complications. Investigators will measure body composition (the amount of fat and muscle in the body and where the fat is stored) using a bioelectrical impedance analysis machine and DEXA scanner. Blood will be drawn for the following labs: HbA1c, lipid panel, comprehensive metabolic panel and leptin. Participants will also answer questions about their diets and consumption of artificial sweeteners.

Key facts

Study ID

NCT03889522

Run by

Medical College of Wisconsin

People needed

21

Starts

2019-05-01

Expected to finish

2021-02-25

Last updated by the study team

2026-03-16

Who can join

Age: 5 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females aged 5-17 years with a clinical diagnosis of T1D of ≥ 6 months in duration
• BMI between the 5th and 95th percentile

You may not qualify if…

• Presence of severe, active disease that requires the use of chronic medication, with the exception of well-controlled autoimmune thyroiditis/hypothyroidism or celiac disease that is well-controlled on a gluten free diet.
• Diabetes other than T1D
• Chronic illness known to affect glucose metabolism
• Psychiatric impairment, with the exception of well-controlled depression or anxiety, that will affect the ability to participate in the study
• Female participants of child-bearing age with reproductive potential must not be knowingly pregnant
• Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation of the study results

Where it is running

• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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