Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
Stopped early · Phase 4
Conditions studied: Aging, Inflammation
In brief
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
Key facts
- Study ID
- NCT03889158
- Run by
- University of Illinois at Chicago
- People needed
- 35
- Starts
- 2019-03-25
- Expected to finish
- 2020-03-13
- Last updated by the study team
- 2021-11-12
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and females willing to provide informed consent
- 18-35 or 55-75 years of age
- Non-smoker
- No use of anti-inflammatory medication within last 2 weeks
- Aerobically trained (defined as performing aerobic exercise on ≥4 days/week, for ≥30 minutes, for at least the past 3 months AND a VO2max ≥75th age- and sex-specific percentile according to ACSM)
- /// OR /// Sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day, < 3 days/week AND a VO2max ≤ 50th age- and sex-specific percentile according to ACSM)
You may not qualify if…
- Body mass index >35 kg/m2
- Pregnancy, hormone replacement therapy, or peri-menopausal
- Known cardiovascular (i.e. atherosclerosis, uncontrolled hypertension, stroke, myocardial infarction, etc.), inflammatory (i.e. Crohn's disease, arthritis, etc.), or metabolic (i.e. Diabetes mellitus) disease
- Medications known to influence cardiovascular outcomes (i.e. heart rate, blood pressure, endothelial function, etc)
- Regular use of medications to reduce inflammation (NSAIDS, aspirin, steroids, etc)
- Bleeding disorders
- Illness, other vaccination, or antioxidant use within 2 weeks prior to screening
- Typhoid vaccination within previous 2 years or prior adverse reaction
- VO2max in 51st - 74th age- and sex-specific percentile according to ACSM (measured during first testing visit)
- Non-English speaking participants
Where it is running
- Integrative Physiology Laboratory, Suite 158 — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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