A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies
Running, not enrolling · Phase 2
Conditions studied: B-cell Non-Hodgkin Lymphoma (B-NHL)
In brief
This study is researching an investigational drug, odronextamab, in adult patients B-cell non-Hodgkin's lymphoma (B-NHL). The main purpose of this study is to assess the effectiveness of odronextamab in destroying cancer cells and to learn more about the safety of odronextamab. The study is looking at several other research questions, including: * To see if odronextamab works to destroy cancer cells * Side effects that may be experienced by people taking odronextamab * How odronextamab works in the body * How much odronextamab is present in the blood
Key facts
- Study ID
- NCT03888105
- Run by
- Regeneron Pharmaceuticals
- People needed
- 515
- Starts
- 2019-11-13
- Expected to finish
- 2028-12-15
- Last updated by the study team
- 2026-07-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Iowa — Iowa City, Iowa, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- John Theurer Cancer Center at Hackensack UMC — Hackensack, New Jersey, United States
- Weill Cornell Medical College New York Presbyterian Hospital — New York, New York, United States
- Stony Brook University Hospital — Stony Brook, New York, United States
- Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States
- Cleveland Clinic Foundation — Cleveland, Ohio, United States
- Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Harold C. Simmons Comprehensive Cancer Center — Dallas, Texas, United States
- Border Medical Oncology — East Albury, New South Wales, Australia
- Northern NSW Local Health District The Tweed Hospital — Tweed Heads, South Wales, Australia
- Epworth Hospital — East Melbourne, Victoria, Australia
- North Building — Frankston, Victoria, Australia
- Andrew Love Cancer Centre — Geelong, Victoria, Australia
- Olivia Newton John Cancer Wellness & Research Centre — Heidelberg, Victoria, Australia
- Royal Perth Hospital — Perth, Western Australia, Australia
- Cross Cancer Institute — Edmonton, Alberta, Canada
- QEII Health Science Centre - Halifax location — Halifax, Nova Scotia, Canada
- Peking University Cancer Hospital (Beijing Cancer Hospital) (Beijing Institute for Cancer Research) — Beijing, Beijing Municipality, China
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China
- Institute of Hematology & Blood Diseases Hospital — Tianjin, Beijing Municipality, China
- Rush University Medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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